Disease overview: The eosinophilias encompass a broad range of non‐hematologic
(secondary or reactive) and hematologic (primary, clonal) disorders with potential for end …

The distinction between chronic eosinophilic leukemia, not otherwise specified and
idiopathic hypereosinophilic syndrome largely relies on clonality assessment. Prior to the …

Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with
driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic …

While high-grade serous ovarian carcinoma (HGSOC) is the most common histologic
subtype of ovarian cancer, significant tumor heterogeneity exists. In addition, chemotherapy …

Lack of demonstrable mutations affecting JAK2, CALR, or MPL driver genes within the
spectrum of BCR-ABL1-negative myeloproliferative neoplasms (MPNs) is currently referred …

Background Metagenomic next-generation sequencing (mNGS) of body fluids is an
emerging approach to identify occult pathogens in undiagnosed patients. We hypothesized …

Background/Aim: Better diagnostic and prognostic markers are required for a more accurate
diagnosis and an earlier detection of glioma progression and for suggesting better treatment …

Purpose Prostate cancer (PCa) has a highly heterogeneous outcome. Beyond Gleason
Score, Prostate Serum Antigen and tumor stage, nowadays there are no biological …

Here, we reviewed clinical-morphological data and investigated mutational profiles by NGS
in a single-center series of 28 consecutive patients admitted to our hospital between …

Hypereosinophilic syndromes (HES) encompass a wide range of disorders characterized by
persistent peripheral blood hypereosinophilia (HE)(ie, an eosinophil count≥ 1.5× 10 9/L …