Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …

DNA polymerase γ is the only known DNA polymerase in human mitochondria and is
essential for mitochondrial DNA replication and repair. It is well established that defects in …

The mitochondria-targeted quinone MitoQ protects mitochondria in animal studies of
pathologies in vivo and is being developed as a therapy for humans. However, it is unclear …

The quantitative polymerase chain reaction (QPCR) assay allows measurement of DNA
damage in the mitochondrial and nuclear genomes without isolation of mitochondria. It also …

Many debilitating conditions are linked to bioenergetic defects. Develo** screens to probe
the genetic and/or chemical basis for such links has proved intractable. Furthermore, there is …

Background Some nucleoside/nucleotide reverse transcriptase inhibitor (NRTI)
combinations cause additive or synergistic interactions in vitro and in vivo. Methods We …

Objectives: The aim of this study was to investigate the possible effects of antiretroviral
therapy (ART) in utero on cardiac development and function in human immunodeficiency …

Quercetin is a natural product that is sold as a supplement in health food stores. While there
are reported benefits for this flavonoid as a dietary supplement due to antioxidant properties …

Phenols are classified as polar narcotics, which are thought to cause toxicity by non-specific
mechanisms, possibly by disrupting membrane structure and function. Here we test three …

Background. Antiretroviral (ARV) regimens during pregnancy are highly effective in
preventing mother-to-child transmission of human immunodeficiency virus (HIV). Congenital …