[HTML][HTML] Polyphenols as antioxidant/pro-oxidant compounds and donors of reducing species: Relationship with human antioxidant metabolism

CMC Andrés, JM Pérez de la Lastra, CA Juan, FJ Plou… - Processes, 2023 - mdpi.com
In this review, we have focused mainly on the study of their antioxidant and pro-oxidant
capacity, and the analysis of the oxidation of the catechol group to o-quinone. The redox …

Tannins in plant–herbivore interactions

RV Barbehenn, CP Constabel - Phytochemistry, 2011 - Elsevier
Tannins are the most abundant secondary metabolites made by plants, commonly ranging
from 5% to 10% dry weight of tree leaves. Tannins can defend leaves against insect …

Formation and biological targets of quinones: cytotoxic versus cytoprotective effects

JL Bolton, T Dunlap - Chemical research in toxicology, 2017 - ACS Publications
Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

Molecular mechanisms of quinone cytotoxicity

PJ O'brien - Chemico-biological interactions, 1991 - Elsevier
Quinones are probably found in all respiring animal and plant cells. They are widely used as
anticancer, antibacterial or antimalarial drugs and as fungicides. Toxicity can arise as a …

Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators

CT Dooley, TM Dore, GT Hanson, WC Jackson… - Journal of Biological …, 2004 - jbc.org
Changes in the redox equilibrium of cells influence a host of cell functions. Alterations in the
redox equilibrium are precipitated by changing either the glutathione/glutathione-disulfide …

Quinone chemistry and toxicity

TJ Monks, RP Hanzlik, GM Cohen, D Ross… - Toxicology and applied …, 1992 - Elsevier
Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds that are found in plants, fungi, and bacteria and that function primarily as …

The chemical biology of naphthoquinones and its environmental implications

Y Kumagai, Y Shinkai, T Miura… - Annual review of …, 2012 - annualreviews.org
Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …

Juglone in oxidative stress and cell signaling

T Ahmad, YJ Suzuki - Antioxidants, 2019 - mdpi.com
Juglone (5-hydroxyl-1, 4-naphthoquinone) is a phenolic compound found in walnuts.
Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat …

Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes

JJ Inbaraj, CF Chignell - Chemical research in toxicology, 2004 - ACS Publications
Juglone (5-hydroxy-1, 4-naphthoquinone) and plumbagin (5-hydroxy-3-methyl-1, 4-
naphthoquinone) are yellow pigments found in black walnut (Juglans regia). Herbal …

Mitochondrial targets of drug toxicity

KB Wallace, AA Starkov - Annual review of pharmacology and …, 2000 - annualreviews.org
Mitochondria have long been recognized as the generators of energy for the cell. Like any
other power source, however, mitochondria are highly vulnerable to inhibition or uncoupling …