Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …

The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …

Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation,
distinguished from rare variations by a requirement for the least abundant allele to have a …

Memory decline in aging results from multiple factors that influence both executive function
and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems …

PURPOSE: The accumulation of numerous or confluent drusen, especially in the macula, is
a significant risk factor for the development of age-related macular degeneration (AMD) …

Alzheimer's disease (AD) is the most common neurodegenerative disease featuring
progressive impairments in memory, cognition, and behavior and ultimately leads to death …

Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various
therapeutic approaches are being used to improve the cholinergic neurotransmission, but …

Dementia refers to a syndrome that is characterised by progressive deterioration of cognitive
functions. Neuropsychiatric symptoms, such as apathy, agitation, and depression, are also …