Design of RNAs: comparing programs for inverse RNA folding

A Churkin, MD Retwitzer, V Reinharz… - Briefings in …, 2018 - academic.oup.com
Computational programs for predicting RNA sequences with desired folding properties have
been extensively developed and expanded in the past several years. Given a secondary …

[HTML][HTML] Solving the RNA inverse folding problem through target structure decomposition and multiobjective evolutionary computation

Á Rubio-Largo, N Lozano-García… - Applied Soft …, 2023 - Elsevier
The RNA inverse folding problem involves discovering a nucleotide sequence that folds into
a desired target structure. Although numerous computational methods have been proposed …

Partial RNA design

F Runge, J Franke, D Fertmann, R Backofen… - …, 2024 - academic.oup.com
Motivation RNA design is a key technique to achieve new functionality in fields like synthetic
biology or biotechnology. Computational tools could help to find such RNA sequences but …

RNA design via structure-aware multifrontier ensemble optimization

T Zhou, N Dai, S Li, M Ward, DH Mathews… - …, 2023 - academic.oup.com
Motivation RNA design is the search for a sequence or set of sequences that will fold to
desired structure, also known as the inverse problem of RNA folding. However, the …

aRNAque: an evolutionary algorithm for inverse pseudoknotted RNA folding inspired by Lévy flights

NSC Merleau, M Smerlak - BMC bioinformatics, 2022 - Springer
Background We study in this work the inverse folding problem for RNA, which is the
discovery of sequences that fold into given target secondary structures. Results We …

DesiRNA: structure-based design of RNA sequences with a replica exchange Monte Carlo approach

TK Wirecki, G Lach, NG Badepally… - Nucleic Acids …, 2025 - academic.oup.com
Designing RNA sequences that form a specific structure remains a challenge. Current
computational methods often struggle with the complexity of RNA structures, especially …

RNAiFold 2.0: a web server and software to design custom and Rfam-based RNA molecules

JA Garcia-Martin, I Dotu, P Clote - Nucleic Acids Research, 2015 - academic.oup.com
Several algorithms for RNA inverse folding have been used to design synthetic riboswitches,
ribozymes and thermoswitches, whose activity has been experimentally validated. The …

RNAGEN: A generative adversarial network-based model to generate synthetic RNA sequences to target proteins

F Ozden, S Barazandeh, D Akboga, SS Tabrizi… - bioRxiv, 2023 - biorxiv.org
RNA-protein binding plays an important role in regulating protein activity by affecting
localization and stability. While proteins are usually targeted via small molecules or other …

Self-playing rna inverse folding

S Obonyo, N Jouandeau, D Owuor - SN Computer Science, 2024 - Springer
Ribonucleic acid (RNA) sequence controls many biological functions in the body of living
organisms including protein synthesis and gene regulations. The sequence folds according …

Approximately Optimal Search on a Higher-dimensional Sliding Puzzle

NSC Merleau, M O'Malley, É Roldán… - arxiv preprint arxiv …, 2024 - arxiv.org
Higher-dimensional sliding puzzles are constructed on the vertices of a $ d $-dimensional
hypercube, where $2^ dl $ vertices are distinctly coloured. Rings with the same colours are …