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Design of RNAs: comparing programs for inverse RNA folding
Computational programs for predicting RNA sequences with desired folding properties have
been extensively developed and expanded in the past several years. Given a secondary …
been extensively developed and expanded in the past several years. Given a secondary …
[HTML][HTML] Solving the RNA inverse folding problem through target structure decomposition and multiobjective evolutionary computation
Á Rubio-Largo, N Lozano-García… - Applied Soft …, 2023 - Elsevier
The RNA inverse folding problem involves discovering a nucleotide sequence that folds into
a desired target structure. Although numerous computational methods have been proposed …
a desired target structure. Although numerous computational methods have been proposed …
Partial RNA design
Motivation RNA design is a key technique to achieve new functionality in fields like synthetic
biology or biotechnology. Computational tools could help to find such RNA sequences but …
biology or biotechnology. Computational tools could help to find such RNA sequences but …
RNA design via structure-aware multifrontier ensemble optimization
Motivation RNA design is the search for a sequence or set of sequences that will fold to
desired structure, also known as the inverse problem of RNA folding. However, the …
desired structure, also known as the inverse problem of RNA folding. However, the …
aRNAque: an evolutionary algorithm for inverse pseudoknotted RNA folding inspired by Lévy flights
NSC Merleau, M Smerlak - BMC bioinformatics, 2022 - Springer
Background We study in this work the inverse folding problem for RNA, which is the
discovery of sequences that fold into given target secondary structures. Results We …
discovery of sequences that fold into given target secondary structures. Results We …
DesiRNA: structure-based design of RNA sequences with a replica exchange Monte Carlo approach
TK Wirecki, G Lach, NG Badepally… - Nucleic Acids …, 2025 - academic.oup.com
Designing RNA sequences that form a specific structure remains a challenge. Current
computational methods often struggle with the complexity of RNA structures, especially …
computational methods often struggle with the complexity of RNA structures, especially …
RNAiFold 2.0: a web server and software to design custom and Rfam-based RNA molecules
Several algorithms for RNA inverse folding have been used to design synthetic riboswitches,
ribozymes and thermoswitches, whose activity has been experimentally validated. The …
ribozymes and thermoswitches, whose activity has been experimentally validated. The …
RNAGEN: A generative adversarial network-based model to generate synthetic RNA sequences to target proteins
RNA-protein binding plays an important role in regulating protein activity by affecting
localization and stability. While proteins are usually targeted via small molecules or other …
localization and stability. While proteins are usually targeted via small molecules or other …
Self-playing rna inverse folding
Ribonucleic acid (RNA) sequence controls many biological functions in the body of living
organisms including protein synthesis and gene regulations. The sequence folds according …
organisms including protein synthesis and gene regulations. The sequence folds according …
Approximately Optimal Search on a Higher-dimensional Sliding Puzzle
NSC Merleau, M O'Malley, É Roldán… - arxiv preprint arxiv …, 2024 - arxiv.org
Higher-dimensional sliding puzzles are constructed on the vertices of a $ d $-dimensional
hypercube, where $2^ dl $ vertices are distinctly coloured. Rings with the same colours are …
hypercube, where $2^ dl $ vertices are distinctly coloured. Rings with the same colours are …