It is estimated that nearly a third of people who abuse drugs started with prescription opioid
medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in …

Opioid receptors (ORs) are undisputed targets for the treatment of pain. Unfortunately,
targeting these receptors therapeutically poses significant challenges including addiction …

The development of physical dependence and addiction disorders due to misuse of opioid
analgesics is a major concern with pain therapeutics. We developed a mouse model of …

The review describes fentanyl and its analogs as new synthetic opioids and the possibilities
of their identification and determination using electrochemical methods (eg, voltammetry …

The need for safer pain-management therapies with decreased abuse liability inspired a
novel drug design that retains μ-opioid receptor (MOR)-mediated analgesia, while …

G protein‐coupled receptors (GPCRs) are the largest family of membrane receptors and
major targets for FDA‐approved drugs. The ability to quantify GPCR expression and ligand …

Neurons integrate inputs over different time and space scales. Fast excitatory synapses at
boutons (ms and μm), and slow modulation over entire dendritic arbors (seconds and mm) …

The opioid crisis in the United States is a significant public health issue, with a nearly
threefold increase in opioid-related fatalities between 1999 and 2014. In response to this …

Introduction The neuroimmune system has emerged as a novel target for the treatment of
substance use disorders (SUDs), with immunomodulation producing encouraging …

Abstract N6‐methyladenosine (m6A) methylation is a vital epigenetic mechanism associated
with drug addiction. However, the relationship between m6A modification and oxycodone …