It is now widely understood that visceral adipose tissue (VAT) is a highly active and dynamic
organ, with many functions beyond lipid accumulation and storage. In this review, we …

Gut microbiota influence anti-tumor immunity, often by producing immune-modulating
metabolites. However, microbes consume a variety of metabolites that may also impact host …

Radiation-induced lung injury is a common complication associated with radiotherapy. It is
characterized by early-stage radiation pneumonia and subsequent radiation pulmonary …

Cryptosporidium is an enteric pathogen and a prominent cause of diarrheal disease
worldwide. Control of Cryptosporidium requires CD4+ T cells, but how protective CD4+ T …

At homeostasis, a substantial proportion of Foxp3+ T regulatory cells (Tregs) have an
activated phenotype associated with enhanced TCR signals and these effector Treg cells …

The radiotherapy‐induced release of DNA fragments can stimulate the cyclic guanosine
monophosphate‐adenosine monophosphate synthase‐stimulator of interferon genes (cGAS …

IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii, but its role in
innate resistance to this organism is unclear. Infection with T. gondii promotes increased …

Initial TCR engagement (priming) of naive CD8+ T cells results in T cell expansion, and
these early events influence the generation of diverse effector and memory populations …

The T-box transcription factor T-bet is regarded as a “master regulator” of CD4+ Th1
differentiation and IFN-γ production. However, in multiple models of infection, T-bet appears …

Background Peritoneal carcinomatosis is an advanced stage of cancer in which the disease
has spread to the peritoneal cavity. In order to restore antitumor immunity subverted by …