Background Old age is characterized by a peculiar low-grade, chronic, and “sterile”
inflammatory state, which has been termed “inflammaging.” This is believed to substantially …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …

Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for
fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and …

It is believed that postponing ageing is more effective and less expensive than the treatment
of particular age-related diseases. Compounds which could delay symptoms of ageing …

The desire of eternal youth seems to be as old as mankind. However, the increasing life
expectancy experienced by populations in developed countries also involves a significantly …

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …

The prevalence of age-related diseases is in an upward trend due to increased life
expectancy in humans. Age-related conditions are among the leading causes of morbidity …

The cellular mechanisms responsible for aging are poorly understood. Aging is considered
as a degenerative process induced by the accumulation of cellular lesions leading …