Plasmodium asexual growth and sexual development in the haematopoietic niche of the host
Plasmodium spp. parasites are the causative agents of malaria in humans and animals, and
they are exceptionally diverse in their morphology and life cycles. They grow and develop in …
they are exceptionally diverse in their morphology and life cycles. They grow and develop in …
Malaria biology and disease pathogenesis: insights for new treatments
Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …
claims the lives of nearly a million children each year in Africa alone and is a top public …
[HTML][HTML] Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum
Transmission represents a population bottleneck in the Plasmodium life cycle and a key
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential …
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential …
Sexual development in Plasmodium parasites: knowing when it's time to commit
Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …
Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system
Humans and mice infected with different Plasmodium strains are known to produce
microvesicles derived from the infected red blood cells (RBCs), denoted RMVs. Studies in …
microvesicles derived from the infected red blood cells (RBCs), denoted RMVs. Studies in …
Antimalarial drug discovery—approaches and progress towards new medicines
Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
Clinical studies and mathematical models predict that, to achieve malaria elimination,
combination therapies will need to incorporate drugs that block the transmission of …
combination therapies will need to incorporate drugs that block the transmission of …
Regulation of sexual commitment and gametocytogenesis in malaria parasites
Sexual differentiation of malaria parasites from the asexual blood stage into gametocytes is
an essential part of the life cycle, as gametocytes are the form that is taken up by the …
an essential part of the life cycle, as gametocytes are the form that is taken up by the …
Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers
T Bousema, RR Dinglasan, I Morlais, LC Gouagna… - 2012 - journals.plos.org
Introduction In the era of malaria elimination and eradication, drug-based and vaccine-
based approaches to reduce malaria transmission are receiving greater attention. Such …
based approaches to reduce malaria transmission are receiving greater attention. Such …
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission
Renewed global efforts toward malaria eradication have highlighted the need for novel
antimalarial agents with activity against multiple stages of the parasite life cycle. We have …
antimalarial agents with activity against multiple stages of the parasite life cycle. We have …