Therapeutic peptides: current applications and future directions
L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …
production, modification, and analytic technologies. Peptides have been produced and …
Synthetic biology and metabolic engineering of actinomycetes for natural product discovery
Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …
medicinal importance. After more than half a century of exploitation, it has become …
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
KAJ Bozhüyük, A Linck, A Tietze, J Kranz, F Wesche… - Nature …, 2019 - nature.com
Non-ribosomal peptide synthetases (NRPSs) are giant enzyme machines that activate
amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of …
amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of …
Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility
INTRODUCTION Nonribosomal peptide synthetases (NRPSs) are microbial megaenzymes
that make a wide variety of small-molecule products, including many that are clinically used …
that make a wide variety of small-molecule products, including many that are clinically used …
Structure, properties, and biological functions of nonribosomal lipopeptides from pseudomonads
Bacteria of the genus Pseudomonas are ubiquitous in nature. Pseudomonads display a
fascinating metabolic diversity, which correlates with their ability to colonize an extremely …
fascinating metabolic diversity, which correlates with their ability to colonize an extremely …
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis
S Dekimpe, J Masschelein - Natural product reports, 2021 - pubs.rsc.org
Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …
molecular machines that produce a wide range of structurally complex peptide natural …
Engineering the biosynthesis of fungal nonribosomal peptides
Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
Non-ribosomal peptide synthetase (NRPS) enzymes form modular assembly-lines, wherein
each module governs the incorporation of a specific monomer into a short peptide product …
each module governs the incorporation of a specific monomer into a short peptide product …
The landscape of recombination events that create nonribosomal peptide diversity
Nonribosomal peptides (NRP) are crucial molecular mediators in microbial ecology and
provide indispensable drugs. Nevertheless, the evolution of the flexible biosynthetic …
provide indispensable drugs. Nevertheless, the evolution of the flexible biosynthetic …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …