The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

The cardiac electrical system is designed to ensure the appropriate rate and timing of
contraction in all regions of the heart, which are essential for effective cardiac function. Well …

About 10 distinct potassium channels in the heart are involved in sha** the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Characteristics of the M Cell. The discovery and characterization of the M cell, a unique cell
type residing in the deep layers of the ventricular myocardium, has opened a new door in …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to sha** the waveforms of action potentials, and several …

The relative contributions of the rapid and slow components of the delayed rectifier
potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration …

There is increased awareness of the impact of gender and gonadal steroids on human
cardiac rhythm and arrhythmias; eg, drugs that prolong repolarization induce torsades de …

A number of gender differences exist in the human electrocardiogram (ECG): the P-wave
and PR intervals are slightly longer in men than in women, whilst women have higher …

Late I Na is an integral part of the sodium current, which persists long after the fast-
inactivating component. The magnitude of the late I Na is relatively small in all species and …