[HTML][HTML] Ginsenoside compound K: Insights into recent studies on pharmacokinetics and health-promoting activities

A Sharma, HJ Lee - Biomolecules, 2020 - mdpi.com
Ginseng (Panax ginseng) is an herb popular for its medicinal and health properties.
Compound K (CK) is a secondary ginsenoside biotransformed from major ginsenosides …

[HTML][HTML] Black ginseng and its saponins: Preparation, phytochemistry and pharmacological effects

AM Metwaly, Z Lianlian, H Luqi, D Deqiang - Molecules, 2019 - mdpi.com
Black ginseng is a type of processed ginseng that is prepared from white or red ginseng by
steaming and drying several times. This process causes extensive changes in types and …

A narrative review of the pharmacology of ginsenoside compound K

T Liu, L Zhu, L Wang - Annals of translational medicine, 2022 - pmc.ncbi.nlm.nih.gov
Background and Objective The ginsenoside compound K [20-o-beta-dglucopyranosyl-20 (S)-
protopanaxadiol; CK] is the main deglycosylated metabolite of ginsenoside. As a rare …

Application of nanoparticles in the treatment of lung cancer with emphasis on receptors

J Wang, T Zhou, Y Liu, S Chen, Z Yu - Frontiers in pharmacology, 2022 - frontiersin.org
Lung cancer is one of the malignant tumors that has seen the most rapid growth in terms of
morbidity and mortality in recent years, posing the biggest threat to people's health and lives …

Functional mechanism of ginsenoside compound K on tumor growth and metastasis

J Liu, Y Wang, Z Yu, G Lv, X Huang… - Integrative cancer …, 2022 - journals.sagepub.com
Ginsenosides, as the most important constituents of ginseng, have been extensively
investigated in cancer chemoprevention and therapeutics. Among the ginsenosides …

Anticancer properties and pharmaceutical applications of ginsenoside compound K: A review

L Zhou, ZK Li, CY Li, YQ Liang… - Chemical biology & drug …, 2022 - Wiley Online Library
Ginsenoside compound K (CK) is the major intestinal bacterial metabolite of ginsenosides
that exhibits anticancer potential in various cancer cells both in vitro and in vivo. The …

Compound K induces endoplasmic reticulum stress and apoptosis in human liver cancer cells by regulating STAT3

X Zhang, S Zhang, Q Sun, W Jiao, Y Yan, X Zhang - Molecules, 2018 - mdpi.com
The ginsenoside compound K (20-O-β-d-glucopyranosyl-20 (S)-protopanaxadiol; CK) is an
intestinal bacterial metabolite of ginseng protopanaxadiol saponin that has been reported to …

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

MB Meng, HH Wang, YL Cui, ZQ Wu, YY Shi… - …, 2016 - pmc.ncbi.nlm.nih.gov
While the mechanisms underlying apoptosis and autophagy have been well characterized
over recent decades, another regulated cell death event, necroptosis, remains poorly …

Ginsenoside metabolite compound K induces apoptosis and autophagy in non-small cell lung cancer cells via AMPK–mTOR and JNK pathways

C Li, Y Dong, L Wang, G Xu, Q Yang… - … and Cell Biology, 2019 - cdnsciencepub.com
Compound K [CK; 20-O-(β-d-glucopyranosyl)-20 (S)-protopanaxadiol], as a metabolite of
ginsenoside, has been verified to have antitumor effects in various cancers, including non …

[HTML][HTML] Effect of ginsenoside CK combined with cisplatin on the proliferation and migration of human cervical cancer HeLa cells via Ras/ERK/MAPK pathway

XL Li, Q Yin, W Wang, RH Ma, ZJ Ni, K Thakur… - Journal of Functional …, 2023 - Elsevier
Ginsenoside (G-CK) has good chemo preventive and anticancer effects. However, its
antimetastatic effects and underlying mechanisms on cervical cancer (CC) are still not clear …