The manner in which a newly synthesized chain of amino acids transforms itself into a
perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence …

Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

From Levinthalto pathways to funnels Page 1 TS 9 1997 Nature Publishing Group http://www.nature.com/nsmb
perspective From Levinthalto pathways to funnels Ken A. Dill and Hue Sun Chan A new …

▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

The new program Dyana (DYnamics Algorithm for Nmr Applications) for efficient calculation
of three-dimensional protein and nucleic acid structures from distance constraints and …

This overview of energy landscapes will focus on some rigorous properties of potential
energy surfaces (PES's), especially the symmetry properties of steepest-descent paths, and …

A common feature of many neurodegenerative diseases is the deposition of β-sheet-rich
amyloid aggregates formed by proteins specific to these diseases. These protein aggregates …

The interactions between proteins, DNA, and RNA in living cells constitute molecular
networks that govern various cellular functions. To investigate the global dynamical …

This review summarises our current understanding of the underlying and universal
mechanism by which newly synthesised proteins achieve their biologically functional states …

Characterizing the equilibrium ensemble of folding pathways, including their relative
probability, is one of the major challenges in protein folding theory today. Although this …