A major goal in structural biology is to unravel how molecular machines function in detail. To
that end, solution-state NMR spectroscopy is ideally suited as it is able to study biological …

The perspective reviews quantitative investigations of chemical exchange phenomena in
proteins and other biological macromolecules using NMR spectroscopy, particularly …

Myriad biological processes proceed through states that defy characterization by
conventional atomic-resolution structural biological methods. The invisibility of these …

Allostery is a ubiquitous biological regulatory process in which distant binding sites within a
protein or enzyme are functionally and thermodynamically coupled. Allosteric interactions …

Methods First, MD ensembles are mapped onto a canonical set of representative fragments,
ie a set of discrete 4-residue states [3]. By this map**, the contribution of rigid fragment …

Die Chemie und Physik der Grenzflächen und Kolloide gehört klassisch in das Gebiet der
Festkörperphysik einerseits und der Thermodynamik andererseits. Erst seit Ende der 1990er …

Proteins and nucleic acids are highly dynamic bio-molecules that can populate a variety of
conformational states. NMR relaxation dispersion (RD) methods are uniquely suited to …

As structural biology trends towards larger and more complex biomolecular targets, a
detailed understanding of their interactions and underlying structures and dynamics is …

In this work an improved stable isotope labeling protocol for nucleic acids is introduced. The
novel building blocks eliminate/minimize homonuclear 13C and 1H scalar couplings thus …

Amino-acid side-chain properties in proteins are key determinants of protein function. NMR
spin relaxation of side chains is an important source of information about local protein …