Infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-
negative bacteria (GNB), including carbapenem-resistant (CR) Enterobacterales (CRE; …

Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported
as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of …

New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all
β-lactams. Twenty-four NDM variants have been identified in> 60 species of 11 bacterial …

The most recent European guidelines and task force reports on hospital-acquired
pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost 10 …

The dramatic increase in the prevalence and clinical impact of infections caused by bacteria
producing carbapenemases is a global health concern. Carbapenemase production is …

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported
as major contributors to non-trauma deaths in the emergency departments worldwide. The …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Abstract Background Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for
the treatment of complicated intra-abdominal and urinary tract infections, as well as hospital …