How cancer hijacks the body's homeostasis through the neuroendocrine system
During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides
AT Slominski, RM Slominski… - … of Physiology-Cell …, 2022 - journals.physiology.org
The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …
largest organ in the human body and it plays a crucial role in the regulation of the body's …
[BOOK][B] Melatoninergic system in the skin
Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …
Neuroendocrinology of the skin
A Slominski, J Wortsman - Endocrine reviews, 2000 - academic.oup.com
The classical observations of the skin as a target for melanotropins have been
complemented by the discovery of their actual production at the local level. In fact, all of the …
complemented by the discovery of their actual production at the local level. In fact, all of the …
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress
A Slominski, J Wortsman, T Luger… - Physiological …, 2000 - journals.physiology.org
The skin is a known target organ for the proopiomelanocortin (POMC)-derived
neuropeptides α-melanocyte stimulating hormone (α-MSH), β-endorphin, and ACTH and …
neuropeptides α-melanocyte stimulating hormone (α-MSH), β-endorphin, and ACTH and …
Key role of CRF in the skin stress response system
AT Slominski, MA Zmijewski, B Zbytek… - Endocrine …, 2013 - academic.oup.com
The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …
POMC: the physiological power of hormone processing
E Harno, T Gali Ramamoorthy, AP Coll… - Physiological …, 2018 - journals.physiology.org
Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …
neuropeptides. In this review, we examine the variability in the individual peptides produced …
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders
RM Slominski, RC Tuckey, PR Manna, AM Jetten… - Genes & …, 2020 - nature.com
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
Stress and psoriasis
L Rousset, B Halioua - International journal of dermatology, 2018 - Wiley Online Library
The links between psoriasis and stress are complex. This article proposes a review of the
literature on the relationship between stress and psoriasis. In 31–88% of cases, patients …
literature on the relationship between stress and psoriasis. In 31–88% of cases, patients …
The significance of CYP11A1 expression in skin physiology and pathology
RM Slominski, C Raman, C Elmets, AM Jetten… - Molecular and cellular …, 2021 - Elsevier
CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …