Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

Abstract S100A8 and S100A9 are calcium-binding proteins predominantly expressed by
neutrophils and monocytes and play key roles in both normal and pathological inflammation …

Deregulations of the expression of the S100A8 and S100A9 genes and/or proteins, as well
as changes in their plasma levels or their levels of secretion in the bone marrow …

Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease that
can be life‐threatening. Gene mutations are found in some cases, but its immune …

Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-
associated inflammation impacts normal niches for haematopoietic progenitor cells and …

Inappropriate localization of proteins can interfere with normal cellular function and drive
tumor development. To understand how this contributes to the development of acute myeloid …

Autophagy is a double-edged sword in tumorigenesis and plays an important role in the
resistance of cancer cells to chemotherapy. S100A8 is a member of the S100 calcium …

S100A8 and S100A9 are multifunctional proteins that can initiate various signaling
pathways and modulate cell function both inside and outside immune cells, depending on …

Mutations in the NADP+-dependent isocitrate dehydrogenase genes 1 and 2 (IDH1 and
IDH2) have recently been found in adult acute myeloid leukemia (AML) patients with a …