TGF-β signaling from receptors to Smads
A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
The widespread regulation of microRNA biogenesis, function and decay
J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
Aberrant regulation and function of microRNAs in cancer
Malignant neoplasms are consistently among the top four leading causes of death in all age
groups in the United States, despite a concerted effort toward develo** novel therapeutic …
groups in the United States, despite a concerted effort toward develo** novel therapeutic …
MicroRNAs and epigenetics
F Sato, S Tsuchiya, SJ Meltzer, K Shimizu - The FEBS journal, 2011 - Wiley Online Library
MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …
MicroRNA biogenesis: regulating the regulators
EF Finnegan, AE Pasquinelli - Critical reviews in biochemistry and …, 2013 - Taylor & Francis
MicroRNAs (miRNAs) function as 21–24 nucleotide guide RNAs that use partial base-
pairing to recognize target messenger RNAs and repress their expression. As a large …
pairing to recognize target messenger RNAs and repress their expression. As a large …
Inhibition and role of let-7d in idiopathic pulmonary fibrosis
KV Pandit, D Corcoran, H Yousef… - American journal of …, 2010 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal
fibrotic lung disease characterized by profound changes in epithelial cell phenotype and …
fibrotic lung disease characterized by profound changes in epithelial cell phenotype and …
miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma
MicroRNAs (miRNAs) are a class of small non-coding RNAs that, in general, negatively
regulate gene expression. They have been identified in various tumor types, showing that …
regulate gene expression. They have been identified in various tumor types, showing that …
Hypoxia: a master regulator of microRNA biogenesis and activity
S Nallamshetty, SY Chan, J Loscalzo - Free Radical Biology and Medicine, 2013 - Elsevier
Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …
changes in a complex regulatory network of transcription factors and signaling proteins to …
Mechanisms of control of microRNA biogenesis
MicroRNAs (miRNAs) are a class of∼ 22 nt non-coding RNAs that control diverse biological
functions in animals, plants and unicellular eukaryotes by promoting degradation or …
functions in animals, plants and unicellular eukaryotes by promoting degradation or …