Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules
ZX He, YP Gong, X Zhang, LY Ma, W Zhao - European journal of medicinal …, 2021 - Elsevier
Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …
way to human health. Pyridazine featuring advantageous physicochemical properties and …
Recent advances of LSD1/KDM1A inhibitors for disease therapy
Abstract Lysine-specific demethylase 1 (LSD1/KDM1A) dysregulation is closely associated
with the pathological processes of various diseases, especially hematologic malignancies …
with the pathological processes of various diseases, especially hematologic malignancies …
New pyrimidine-5-carbonitriles as COX-2 inhibitors: design, synthesis, anticancer screening, molecular docking, and in silico ADME profile studies
Two series of cyanopyrimidine hybrids were synthesized bearing either benzo [d] imidazole,
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …
Design and synthesis of pyrazole–pyrazoline hybrids as cancer‐associated selective COX‐2 inhibitors
In continuation of our previous work on cancer and inflammation, 15 novel pyrazole–
pyrazoline hybrids (WSPP1–15) were synthesized and fully characterized. The formation of …
pyrazoline hybrids (WSPP1–15) were synthesized and fully characterized. The formation of …
Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific …
A series of novel cyanopyrimidine-hydrazone hybrids were synthesized and characterized
with various spectroscopic techniques. The synthesized compounds were tested at NCI …
with various spectroscopic techniques. The synthesized compounds were tested at NCI …
Synthesis, COX-2 inhibition and metabolic stability studies of 6-(4-fluorophenyl)-pyrimidine-5-carbonitrile derivatives as anticancer and anti-inflammatory agents
In continuation of previous work on cyanopyrimidine derivatives for cancer and
inflammation, eighteen novel amino containing cyanopyrimidine derivatives (4a-p) bearing …
inflammation, eighteen novel amino containing cyanopyrimidine derivatives (4a-p) bearing …
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies
Background The pyridazinone nucleus has been incorporated into a wide variety of
therapeutically interesting molecules to transform them into better drugs …
therapeutically interesting molecules to transform them into better drugs …
Synthesis, ADMET prediction and reverse screening study of 3, 4, 5-trimethoxy phenyl ring pendant sulfur‐containing cyanopyrimidine derivatives as promising …
Cancer remains considered as one of the leading global health problems either due to
meagre and suboptimal therapeutic response of chemotherapeutic agents or due to the …
meagre and suboptimal therapeutic response of chemotherapeutic agents or due to the …
Halogen‐based quinazolin‐4(3H)‐one derivatives as MCF‐7 breast cancer inhibitors: Current developments and structure–activity relationship
R Upadhyay, P Tandel, AB Patel - Archiv der Pharmazie, 2025 - Wiley Online Library
Currently, cancer is a serious health challenge with predominance beyond restrictions.
Breast cancer remains one of the major contributors to cancer‐related morbidity and …
Breast cancer remains one of the major contributors to cancer‐related morbidity and …
An Overview of synthesis and biological activity of dihydropyrimidine derivatives
AC Dudhe, R Dudhe, O Porwal… - Mini Reviews in …, 2022 - benthamdirect.com
Dihydropyrimidine derivatives are the most important scaffolds due to structural similarities
with natural products; it is a heterocyclic compound. The chemistry of Dihydropyrimidine is a …
with natural products; it is a heterocyclic compound. The chemistry of Dihydropyrimidine is a …