With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

Highly efficient data-collection methods are required for successful macromolecular
crystallography (MX) experiments at X-ray free-electron lasers (XFELs). XFEL beamtime is …

The photoisomerization reaction of a fluorescent protein chromophore occurs on the ultrafast
timescale. The structural dynamics that result from femtosecond optical excitation have …

Background Ever since the first atomic structure of an enzyme was solved, the discovery of
the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal …

The advent of the X-ray free electron laser (XFEL) in the last decade created the discipline of
serial crystallography but also the challenge of how crystal samples are delivered to X-ray …

Crystallography has made a notable contribution to our knowledge of structural biology. For
traditional crystallography experiments, the growth of crystals with large size and high …

Carrying out macromolecular crystallography (MX) experiments at cryogenic temperatures
significantly slows the rate of global radiation damage, thus facilitating the solution of high …

Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) is an
emerging field for structural biology. One of its major impacts lies in the ability to reveal the …

Diffraction-limited lens-based optical microscopy fails to discern fluorescent features closer
than∼ 200 nm. All super-resolution microscopy (nanoscopy) approaches that fundamentally …

Serial femtosecond crystallography (SFX) has enabled determination of room temperature
structures of proteins with minimum radiation damage. A highly viscous grease matrix acting …