DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

In this review, we provide an organized summary of the theoretical and computational
results that are available for polymers subject to spatial or topological constraints. Because …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

The power of nanofluidic channels to analyze DNA is described along with practical
experimental hints. As an introduction, a general overview is given on conventional DNA …

We have used a realistic model for double-stranded DNA and Monte Carlo simulations to
compute the extension (mean span) of a DNA molecule confined in a nanochannel over the …

Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules.
Nanofluidic systems have been used to probe conformational, dynamic, and entropic …

Optical DNA map** has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

In recent years, applications and experimental studies of DNA in nanochannels have
stimulated the investigation of the polymer physics of DNA in confinement. Recent advances …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …