Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic
acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

One of the most common malignant tumors is hepatocellular carcinoma (HCC). Progression
of HCC mainly results from highly complex molecular and pathological pathways. Midkine …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Metazoan life is dependent upon the utilization of O2 for essential metabolic processes and
oxygen homeostasis is an organizing principle for understanding metazoan evolution …

The survival of metazoan organisms is dependent upon the utilization of O2 as a substrate
for COX (cytochrome c oxidase), which constitutes Complex IV of the mitochondrial …

Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

Abstract mTORC1 is hyperactive in multiple cancer types,. Here, we performed integrative
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …

The phylogenetically conserved nuclear factor I (NFI) gene family encodes site-specific
transcription factors essential for the development of a number of organ systems. We …