Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

Platelets play an important role in the vessel. Following their formation from
megakaryocytes, platelets exist in circulation for 5–7 days and primarily function as …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

Blood platelets are critical for hemostasis and thrombosis and play diverse roles during
immune responses. Despite these versatile tasks in mammalian biology, their skills on a …

Antiplatelet drugs, such as aspirin, P2Y12 antagonists, and glycoprotein (GP) IIb/IIIa
inhibitors, have proved to be successful in reducing the morbidity and mortality associated …

Ten percent of deaths worldwide are due to trauma, and it is the third most common cause of
death in the United States. Despite a profound upregulation in procoagulant mechanisms …

Platelets are essential for clotting in the blood and maintenance of normal hemostasis.
Under pathologic conditions such as atherosclerosis, vascular injury often results in …

A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

Hemostasis requires the tightly regulated interaction of the coagulation system, platelets,
other blood cells and components of the vessel wall at a site of vascular injury. The …