Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Anti-diabetic drugs recent approaches and advancements
J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
Identification of 1, 3, 4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
D **ao, L Lu, B Liang, Z **ong, X Xu… - European Journal of …, 2023 - Elsevier
In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
Design and synthesis of novel quinazolinone-1, 2, 3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study
A novel series of quinazolinone-1, 2, 3-triazole hybrids 10a-p were designed, synthesized,
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …
Searching potential antiviral candidates for the treatment of the 2019 novel coronavirus based on DFT calculations and molecular docking
A Sagaama, SA Brandan, TB Issa, N Issaoui - Heliyon, 2020 - cell.com
In the present work, the succinic acid (SA), L-pyroglutamic acid (L-PGA), N-phenyl-
thioacetamide (N-NPTA), 2-amino-5-chloropyridine hydrogen succinate (ACPS) …
thioacetamide (N-NPTA), 2-amino-5-chloropyridine hydrogen succinate (ACPS) …
Design, synthesis, and in silico studies of quinoline-based-benzo [d] imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
M Noori, A Davoodi, A Iraji, N Dastyafteh, M Khalili… - Scientific Reports, 2022 - nature.com
In this study, 18 novel quinoline-based-benzo [d] imidazole derivatives were synthesized
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
Recent advances of α-glucosidase inhibitors: A comprehensive review
Background: Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Synthesis, in vitro inhibitor screening, structure–activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α …
New series of thioquinoline structures bearing phenylacetamide 9a–p were designed,
synthesized and the structure of all derivatives was confirmed using different spectroscopic …
synthesized and the structure of all derivatives was confirmed using different spectroscopic …
Design, synthesis, and in silico studies of benzimidazole bearing phenoxyacetamide derivatives as α-glucosidase and α-amylase inhibitors
N Shayegan, A Iraji, N Bakhshi, A Moazzam… - Journal of Molecular …, 2022 - Elsevier
Benzimidazole bearing phenoxyacetamide derivatives 7a-l were designed and synthesized
as anti-diabetic agents. All derivatives were evaluated for in vitro α-glucosidase and α …
as anti-diabetic agents. All derivatives were evaluated for in vitro α-glucosidase and α …