Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid

MS García-Ayllón, DH Small, J Avila… - Frontiers in molecular …, 2011 - frontiersin.org
A common feature in the Alzheimer's disease (AD) brain is the presence of
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …

Reconsideration of anticholinesterase therapeutic strategies against Alzheimer's disease

H Wang, H Zhang - ACS chemical neuroscience, 2018 - ACS Publications
Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

Modulators of acetylcholinesterase activity: From Alzheimer's disease to anti-cancer drugs

T Lazarevic-Pasti, A Leskovac, T Momic… - Current medicinal …, 2017 - ingentaconnect.com
Background: Acetylcholinesterase (AChE) is involved in the termination of impulse
transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous …

Glutamate mediated signaling in the pathophysiology of autism spectrum disorders

PR Choudhury, S Lahiri, U Rajamma - Pharmacology Biochemistry and …, 2012 - Elsevier
Autism spectrum disorder (ASD) is a childhood neurodevelopmental disorder. During fetal
and neonatal brain development, the cues for neurodevelopment are regulated in a well …

Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau …

J Del Pino, G Zeballos, MJ Anadón, P Moyano… - Archives of …, 2016 - Springer
Cadmium is a neurotoxic compound which induces cognitive alterations similar to those
produced by Alzheimer's disease (AD). However, the mechanism through which cadmium …

Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression

MÁ Cortés‐Gómez, E Llorens‐Álvarez… - Journal of …, 2021 - Wiley Online Library
In Alzheimer's disease (AD), the enzyme acetylcholinesterase (AChE) co‐localizes with
hyperphosphorylated tau (P‐tau) within neurofibrillary tangles. Having demonstrated that …

Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer's disease

JX Pan, D Lee, D Sun, K Zhao, L **ong, HH Guo… - Cell Death & …, 2022 - nature.com
Alzheimer's disease (AD) is the most common form of dementia. Notably, patients with AD
often suffer from severe sarcopenia. However, their direct link and relationship remain poorly …

Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through …

P Moyano, A Flores, J García, JM García… - Food and Chemical …, 2021 - Elsevier
Abstract Bisphenol-A (BPA), a widely used plasticizer, induces cognitive dysfunctions
following single and repeated exposure. Several studies, developed in hippocampus and …

Neuronal AChE splice variants and their non‐hydrolytic functions: redefining a target of AChE inhibitors?

M Zimmermann - British journal of pharmacology, 2013 - Wiley Online Library
AChE enzymatic inhibition is a core focus of pharmacological intervention in A lzheimer's
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …

From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors

P Russo, A Frustaci, A Del Bufalo, M Fini… - Current medicinal …, 2013 - benthamdirect.com
The leading Alzheimer's disease (AD) therapeutics to date involves inhibitors of
acetylcholinesterase (AChE), which should, in principle, elevate cholinergic signaling and …