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Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid
MS García-Ayllón, DH Small, J Avila… - Frontiers in molecular …, 2011 - frontiersin.org
A common feature in the Alzheimer's disease (AD) brain is the presence of
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …
Reconsideration of anticholinesterase therapeutic strategies against Alzheimer's disease
H Wang, H Zhang - ACS chemical neuroscience, 2018 - ACS Publications
Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …
Modulators of acetylcholinesterase activity: From Alzheimer's disease to anti-cancer drugs
Background: Acetylcholinesterase (AChE) is involved in the termination of impulse
transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous …
transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous …
Glutamate mediated signaling in the pathophysiology of autism spectrum disorders
PR Choudhury, S Lahiri, U Rajamma - Pharmacology Biochemistry and …, 2012 - Elsevier
Autism spectrum disorder (ASD) is a childhood neurodevelopmental disorder. During fetal
and neonatal brain development, the cues for neurodevelopment are regulated in a well …
and neonatal brain development, the cues for neurodevelopment are regulated in a well …
Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau …
J Del Pino, G Zeballos, MJ Anadón, P Moyano… - Archives of …, 2016 - Springer
Cadmium is a neurotoxic compound which induces cognitive alterations similar to those
produced by Alzheimer's disease (AD). However, the mechanism through which cadmium …
produced by Alzheimer's disease (AD). However, the mechanism through which cadmium …
Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression
MÁ Cortés‐Gómez, E Llorens‐Álvarez… - Journal of …, 2021 - Wiley Online Library
In Alzheimer's disease (AD), the enzyme acetylcholinesterase (AChE) co‐localizes with
hyperphosphorylated tau (P‐tau) within neurofibrillary tangles. Having demonstrated that …
hyperphosphorylated tau (P‐tau) within neurofibrillary tangles. Having demonstrated that …
Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia. Notably, patients with AD
often suffer from severe sarcopenia. However, their direct link and relationship remain poorly …
often suffer from severe sarcopenia. However, their direct link and relationship remain poorly …
Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through …
Abstract Bisphenol-A (BPA), a widely used plasticizer, induces cognitive dysfunctions
following single and repeated exposure. Several studies, developed in hippocampus and …
following single and repeated exposure. Several studies, developed in hippocampus and …
Neuronal AChE splice variants and their non‐hydrolytic functions: redefining a target of AChE inhibitors?
M Zimmermann - British journal of pharmacology, 2013 - Wiley Online Library
AChE enzymatic inhibition is a core focus of pharmacological intervention in A lzheimer's
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …
From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors
P Russo, A Frustaci, A Del Bufalo, M Fini… - Current medicinal …, 2013 - benthamdirect.com
The leading Alzheimer's disease (AD) therapeutics to date involves inhibitors of
acetylcholinesterase (AChE), which should, in principle, elevate cholinergic signaling and …
acetylcholinesterase (AChE), which should, in principle, elevate cholinergic signaling and …