Parkinson's Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss
of dopaminergic neurons within the nigral-striatal pathway. Multiple lines of evidence …

Abstract Major Depressive Disorder (MDD) is common among cancer patients, with
prevalence rates up to four-times higher than the general population. Depression confers …

Alzheimer's disease (AD) is arguably the most common cause of dementia in the elderly and
is marked by progressive synaptic degeneration, which in turn leads to cognitive decline …

Oxidative stress has been hypothesized to play a role in the pathophysiology of Alzheimer's
disease (AD). Previously, we found that total nitrosylated protein levels were increased in …

Nitric oxide (NO) represents an important signaling molecule which modulates the functions
of different organs, including the brain. S-nitrosylation (SNO), a post-translational …

Extracellular vesicles (EVs) are membranous structures released by cells into the
extracellular space and are thought to be involved in cell‐to‐cell communication. While EVs …

Rationale Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine
reuptake inhibitors (SNRIs) are the most commonly used drugs for the treatment of …

Background/Objectives: Parkinson's disease (PD) is a progressive neurodegenerative
disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars …

Chronic stress is a key contributor to depression. Previous studies have shown that oxidative
stress and inflammation are increased by chronic stress and in subjects with depression …

Previous studies have shown that chronic stress and chronic stress hormone treatment
induce oxidative damage in rodents. Thioredoxin (Trx) is a small redox protein that plays an …