Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

[HTML][HTML] Language impairments in people with autoimmune neurological diseases: A sco** review

J Rook, S Llufriu, D de Kok, A Rofes - Journal of communication disorders, 2023 - Elsevier
Abstract Introduction Autoimmune neurological diseases (ANDs) are a specific type of
autoimmune disease that affect cells within the central and peripheral nervous system …

The Symbol Digit Modalities Test (SDMT) is sensitive but non-specific in MS: Lexical access speed, memory, and information processing speed independently …

J Sandry, DV Simonet, R Brandstadter, S Krieger… - Multiple sclerosis and …, 2021 - Elsevier
Abstract Background The Symbol Digit Modalities Test (SDMT) is the most sensitive metric of
neurocognitive function in multiple sclerosis (MS), and is consistently interpreted as a …

Staging and stratifying cognitive dysfunction in multiple sclerosis

C Wojcik, TA Fuchs, H Tran, MG Dwyer… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: The sequence in which cognitive domains become impaired in multiple
sclerosis (MS) is yet to be formally demonstrated. It is unclear whether processing speed …

EDSS 0 is not normal: multiple sclerosis disease burden below the clinical threshold

SC Krieger, A Antoine… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Little to no above-threshold deficits may be evident in early multiple sclerosis (MS). The
Expanded Disability Status Scale (EDSS) is a standard measure of neurologic function, with …

Cognitive processes underlying verbal fluency in multiple sclerosis

A Delgado-Álvarez, JA Matias-Guiu… - Frontiers in …, 2021 - frontiersin.org
Background: Verbal fluency (VF) has been associated with several cognitive functions, but
the cognitive processes underlying verbal fluency deficits in Multiple Sclerosis (MS) are …

Classifying multiple sclerosis patients on the basis of SDMT performance using machine learning

K Buyukturkoglu, D Zeng, S Bharadwaj… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Objective: To build a model to predict cognitive status reflecting structural, functional, and
white matter integrity changes in early multiple sclerosis (MS). Methods: Based on Symbol …

Social support is linked to mental health, quality of life, and motor function in multiple sclerosis

A Kever, K Buyukturkoglu, CS Riley, PL De Jager… - Journal of …, 2021 - Springer
Objective To investigate associations of social support to psychological well-being,
cognition, and motor functioning in patients with multiple sclerosis (MS). Secondarily, we …

Depression symptoms and cognition in multiple sclerosis: Longitudinal evidence of a specific link to executive control

JR Anderson, KC Fitzgerald… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: Depression symptoms are prevalent in multiple sclerosis (MS) and associated
with poorer cognition in cross-sectional studies; it is unknown whether changes in …

Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis

ES Beck, J Maranzano, NJ Luciano… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Dramatic improvements in visualization of cortical (especially subpial) multiple
sclerosis (MS) lesions allow assessment of impact on clinical course. Objective …