Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others …

Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

The study of cognitive change across a life span, both in pathological and healthy samples,
has been heavily influenced by developments in cognitive psychology as a theoretical …

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …

As the spread of COVID-19 has led to global efforts to social distance, concerns about the
negative psychological effects of social isolation and loneliness have grown. The purpose of …

This study examined the Big Five personality traits as predictors of mortality risk, and
smoking as a mediator of that association. Replication was built into the fabric of our design …

The heritability of Alzheimer's disease estimated from twin studies is greater than the
heritability derived from genome-based studies, for reasons that remain unclear. We apply …