Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-develo**
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme
with the unique property to participate in both the citric acid cycle and the electron transport …

The wide scale use of Zinc oxide (ZnO) nanoparticles in the world consumer market makes
human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. The …

Zinc oxide (ZnO) nanoparticles are finding applications in a wide range of products including
cosmetics, food packaging, imaging, etc. This increases the likelihood of human exposure to …

Calcium is an essential intracellular messenger that plays a vital role in controlling a broad
range of cellular processes, including apoptosis. This review offers an in-depth analysis of …

A New Avenue of Research Beyond Traditional Studies of Vitamin E In the current literature,
more than 95% of all studies of vitamin E are directed toward the specific exploration of the …

The past decade has revealed a new role for the mitochondria in cell metabolism–regulation
of cell death pathways. Considering that most tumor cells are resistant to apoptosis, one …

The current understanding of the complex role of ROS in the organism and pathological
sequelae of oxidative stress points to the necessity of comprehensive studies of antioxidant …

Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA)
cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing …

Abstract Elesclomol (formerly STA-4783) is a novel small molecule undergoing clinical
evaluation in a pivotal phase III melanoma trial (SYMMETRY). In a phase II randomized …