Though dentin hypersensitivity (DHS) is one of the most common complaints from patients in
dental clinics, there are no universally accepted guidelines for differential diagnosis as well …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Carious lesion dynamics are dependent predominantly on the availability of fermentable
sugars, other environmental conditions, bacteria, and host factors. Our current …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …

Odontoblasts are specialized cells that produce dentin and exhibit unique morphological
characteristics; ie, they extend cytoplasmic processes into dentinal tubules. While …

Recent studies have demonstrated that the lipopolysaccharide (LPS) receptor (TLR4) is
expressed in TRPV1 containing trigeminal sensory neurons. In this study, we evaluated …

Introduction Although many clinical studies have reported on the prevalence of dental pain,
far fewer studies have focused on the mechanisms of dental pain. This is an important gap …

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …

Migraine remains an elusive and poorly understood disease. The uncertainty is reflected by
the currently unsatisfactory acute and prophylactic treatments for this disease. Genetic and …