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Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: Overview and perspectives
Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …
excitation-contraction coupling. The calcium spark, the fundamental element of the …
Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal Ca2+
DA Terrar - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Rhythms of electrical activity in all regions of the heart can be influenced by a variety of
intracellular membrane bound organelles. This is true both for normal pacemaker activity …
intracellular membrane bound organelles. This is true both for normal pacemaker activity …
[HTML][HTML] Modeling calcium cycling in the heart: Progress, pitfalls, and challenges
Intracellular calcium (Ca) cycling in the heart plays key roles in excitation–contraction
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …
Intracellular signaling pathways mediating tyrosine kinase inhibitor cardiotoxicity
Tyrosine kinase inhibitor (TKI) therapy has improved the survival of several cancers in the
United States, including metastatic renal cell carcinoma (mRCC), hepatocellular carcinoma …
United States, including metastatic renal cell carcinoma (mRCC), hepatocellular carcinoma …