Abstract Purpose of Review There have been significant advances in the treatment of
relapsed/refractory chronic lymphocytic leukemia (CLL) over the past two decades …

Clonal expansion of B-cells, from the early stages of monoclonal B-cell lymphocytosis
through to chronic lymphocytic leukemia (CLL), and then in some cases to Richter's …

Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic
proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have …

Survival is widely considered the most important endpoint in cancer clinical trials. However,
in some cancers such as chronic lymphocytic leukaemia (CLL) observing a survival …

In the modern era of Chronic Lymphocytic Leukemia (CLL) targeted therapy, the loss of p53
function due to genetic abnormalities remains a significant challenge. This is because even …

A Molecular Features Set (MFS), is a result of a vast diversity of bioinformatics pipelines. The
lack of a “gold standard” for most experimental data modalities makes it difficult to provide …

Background: In humans, age-related DNA methylation has been studied in blood, tissues,
buccal swabs, and fibroblasts, and changes in DNA methylation patterns according to age …

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for
European Hematology Research 1 aiming to highlight achievements in the diagnostics and …

Advanced genome-wide association studies (GWAS) identified several transforming
mutations in susceptible loci which are recognized as valuable prognostic markers in …

A Blanca y Maria José, mis directoras de tesis. Gracias por darme la oportunidad de
adentrarme en el mundo laboral, por ayudar a desarrollarme como profesional y por …