Recent advances of imidazole-containing derivatives as anti-tubercular agents

YL Fan, XH **, ZP Huang, HF Yu, ZG Zeng… - European journal of …, 2018‏ - Elsevier
Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Prodrug design to improve pharmacokinetic and drug delivery properties: challenges to the discovery scientists

S Jana, S Mandlekar, P Marathe - Current medicinal chemistry, 2010‏ - ingentaconnect.com
The prodrug design is a versatile, powerful method that can be applied to a wide range of
parent drug molecules, administration routes, and formulations. Clinically, the majority of …

Nitro-group-containing drugs

K Nepali, HY Lee, JP Liou - Journal of medicinal chemistry, 2018‏ - ACS Publications
The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Photoredox cross-coupling: Ir/Ni dual catalysis for the synthesis of benzylic ethers

I Karakaya, DN Primer, GA Molander - Organic letters, 2015‏ - ACS Publications
Single-electron transmetalation has emerged as an enabling paradigm for the cross-
coupling of Csp3 hybridized organotrifluoroborates. Cross-coupling of α …

Antituberculosis drug research: a critical overview

Beena, DS Rawat - Medicinal research reviews, 2013‏ - Wiley Online Library
The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …

An efficient one-pot synthesis of heterocycle-fused 1, 2, 3-triazole derivatives as anti-cancer agents

SJ Yan, YJ Liu, YL Chen, L Liu, J Lin - Bioorganic & Medicinal Chemistry …, 2010‏ - Elsevier
A series of heterocycle-fused 1, 2, 3-triazoles were easily prepared by the 1, 3-dipolar
cycloaddition of heterocyclic ketene aminals or N, O-acetals with sodium azide and polyhalo …

Prodrugs: bridging pharmacodynamic/pharmacokinetic gaps

B Testa - Current opinion in chemical biology, 2009‏ - Elsevier
In this mini review, prodrugs are discussed with a focus on their pharmaceutical,
pharmacokinetic, and pharmacodynamic objectives, as well as on the resulting therapeutic …

[HTML][HTML] Nitroaromatic antibiotics as nitrogen oxide sources

AM Rice, Y Long, SB King - Biomolecules, 2021‏ - mdpi.com
Nitroaromatic antibiotics show activity against anaerobic bacteria and parasites, finding use
in the treatment of Heliobacter pylori infections, tuberculosis, trichomoniasis, human African …

Nitroimidazoles for the treatment of TB: past, present and future

T Mukherjee, H Boshoff - Future medicinal chemistry, 2011‏ - Taylor & Francis
Tuberculosis remains a leading cause of death resulting from an infectious agent, and the
spread of multi-and extensively drug-resistant strains of Mycobacterium tuberculosis poses a …

Highly enantioselective, hydrogen-bond-donor catalyzed additions to oxetanes

DA Strassfeld, ZK Wickens, E Picazo… - Journal of the …, 2020‏ - ACS Publications
A precisely designed chiral squaramide derivative is shown to promote the highly
enantioselective addition of trimethylsilyl bromide (TMSBr) to a broad variety of 3-substituted …