Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

Tracking placental development in health and disease

JD Aplin, JE Myers, K Timms… - Nature Reviews …, 2020 - nature.com
Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

The glomerular filtration barrier: a structural target for novel kidney therapies

IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring

R Fox, J Kitt, P Leeson, CYL Aye… - Journal of clinical …, 2019 - mdpi.com
Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which
includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Pre-eclampsia: its pathogenesis and pathophysiolgy: review articles

P Gathiram, J Moodley - Cardiovascular journal of Africa, 2016 - journals.co.za
Pre-eclampsia is a pregnancy-specific disorder that has a worldwide prevalence of 5-8%. It
is one of the main causes of maternal and perinatal morbidity and mortality globally and …

Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors

T Tomimatsu, K Mimura, S Matsuzaki, M Endo… - International journal of …, 2019 - mdpi.com
Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …

Preeclampsia: pathogenesis, prevention, and long-term complications

B Jim, SA Karumanchi - Seminars in nephrology, 2017 - Elsevier
Preeclampsia continues to afflict 5% to 8% of all pregnancies throughout the world and is
associated with significant morbidity and mortality to the mother and the fetus. Although the …

Preeclampsia: novel mechanisms and potential therapeutic approaches

Z Armaly, JE Jadaon, A Jabbour, ZA Abassi - Frontiers in physiology, 2018 - frontiersin.org
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …