Atopic dermatitis endotypes and implications for targeted therapeutics

T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

Histone modifications and their role in epigenetics of atopy and allergic diseases

B Alaskhar Alhamwe, R Khalaila, J Wolf… - Allergy, Asthma & …, 2018 - Springer
This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …

Perinatal and early-life nutrition, epigenetics, and allergy

N Acevedo, B Alashkar Alhamwe, L Caraballo, M Ding… - Nutrients, 2021 - mdpi.com
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

Endophenotypic variations of atopic dermatitis by age, race, and ethnicity

T Nomura, J Wu, K Kabashima… - The Journal of Allergy and …, 2020 - Elsevier
Atopic dermatitis (AD) is a heterogeneous disease with unique clinical manifestations across
age groups and race/ethnicities. Characteristic molecular mechanisms, known as …

The impact of milk and its components on epigenetic programming of immune function in early life and beyond: implications for allergy and asthma

BCAM Esch, M Porbahaie, S Abbring… - Frontiers in …, 2020 - frontiersin.org
Specific and adequate nutrition during pregnancy and early life is an important factor in
avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular …

[HTML][HTML] Influence of the bioactive diet components on the gene expression regulation

J Mierziak, K Kostyn, A Boba, M Czemplik, A Kulma… - Nutrients, 2021 - mdpi.com
Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food
constituents, which can transfer information from the external environment and influence …

Novel Perspective on the Regulation of Offspring Food Allergy by Maternal Diet and Nutrients

T Bai, Z Wang, H Shao, X Zhang, A Lorenz… - Journal of Agricultural …, 2024 - ACS Publications
There has been a dramatic surge in the prevalence of food allergy (FA) that cannot be
explained solely by genetics, identifying mechanisms of sensitization that are driven by …

[HTML][HTML] Anti-inflammatory function of fatty acids and involvement of their metabolites in the resolution of inflammation in chronic obstructive pulmonary disease

S Kotlyarov, A Kotlyarova - International Journal of Molecular Sciences, 2021 - mdpi.com
Lipid metabolism plays an important role in many lung functions. Disorders of lipid
metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD) …

Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

D Martino, M Neeland, T Dang, J Cobb, J Ellis… - Nature …, 2018 - nature.com
Food allergy poses a significant clinical and public health burden affecting 2–10% of infants.
Using integrated DNA methylation and transcriptomic profiling, we found that polyclonal …

[HTML][HTML] Recent developments in the role of histone acetylation in asthma

DP Potaczek, S Bazan-Socha, E Wypasek… - … Archives of Allergy and …, 2024 - karger.com
Background: Epigenetic modifications are known to mediate both beneficial and unfavorable
effects of environmental exposures on the development and clinical course of asthma. On …