Reg3γ: current understanding and future therapeutic opportunities in metabolic disease

JH Shin, N Bozadjieva-Kramer… - Experimental & molecular …, 2023 - nature.com
Regenerating family member gamma, Reg3γ (the mouse homolog of human REG3A),
belonging to the antimicrobial peptides (AMPs), functions as a part of the host immune …

Ryanodine receptor structure and function in health and disease

G Santulli, D Lewis, A des Georges, AR Marks… - … : structure and function, 2018 - Springer
Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …

SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients

P Mone, F Varzideh, SS Jankauskas, A Pansini… - …, 2022 - ahajournals.org
Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

[LIBRO][B] Nutraceuticals and dietary supplements: Applications in health improvement and disease management

RK Keservani, AK Sharma, RK Kesharwani - 2020 - books.google.com
Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional
foods, this comprehensive and timely book presents an abundance of information on herbal …

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

D Amgalan, TP Garner, R Pekson, XF Jia… - Nature cancer, 2020 - nature.com
Doxorubicin remains an essential component of many cancer regimens, but its use is limited
by lethal cardiomyopathy, which has been difficult to target, owing to pleiotropic mechanisms …

Ketone bodies rescue mitochondrial dysfunction via epigenetic remodeling

J Gambardella, SS Jankauskas, U Kansakar… - Basic to Translational …, 2023 - jacc.org
Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact
molecular processes underlying this disorder are not fully known. This study includes a …

Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo

X Wang, MB Morelli, A Matarese, C Sardu… - ESC heart …, 2020 - Wiley Online Library
Aims We hypothesize that specific microRNAs (miRNAs) within cardiomyocyte‐derived
exosomes play a pivotal role in the phenoconversion of cardiac myofibroblasts following …

No time to die—how islets meet their demise in transplantation

A Kale, NM Rogers - Cells, 2023 - mdpi.com
Islet transplantation represents an effective treatment for patients with type 1 diabetes
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …

Interferon alpha: The key trigger of type 1 diabetes

A Lombardi, E Tsomos, SS Hammerstad… - Journal of autoimmunity, 2018 - Elsevier
IFNα is a cytokine essential to a vast array of immunologic processes. Its induction early in
the innate immune response provides a priming mechanism that orchestrates numerous …

Molecular aspects of pancreatic β‐cell dysfunction: oxidative stress, microRNA, and long noncoding RNA

MJ Saeedi Borujeni, E Esfandiary… - Journal of Cellular …, 2019 - Wiley Online Library
Metabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This
disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction …