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Reg3γ: current understanding and future therapeutic opportunities in metabolic disease
Regenerating family member gamma, Reg3γ (the mouse homolog of human REG3A),
belonging to the antimicrobial peptides (AMPs), functions as a part of the host immune …
belonging to the antimicrobial peptides (AMPs), functions as a part of the host immune …
Ryanodine receptor structure and function in health and disease
Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …
required for the function of many organs including heart and skeletal muscle, synaptic …
SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients
Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …
hypertension and diabetes, and both these conditions are associated with endothelial …
[LIBRO][B] Nutraceuticals and dietary supplements: Applications in health improvement and disease management
RK Keservani, AK Sharma, RK Kesharwani - 2020 - books.google.com
Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional
foods, this comprehensive and timely book presents an abundance of information on herbal …
foods, this comprehensive and timely book presents an abundance of information on herbal …
A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy
Doxorubicin remains an essential component of many cancer regimens, but its use is limited
by lethal cardiomyopathy, which has been difficult to target, owing to pleiotropic mechanisms …
by lethal cardiomyopathy, which has been difficult to target, owing to pleiotropic mechanisms …
Ketone bodies rescue mitochondrial dysfunction via epigenetic remodeling
Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact
molecular processes underlying this disorder are not fully known. This study includes a …
molecular processes underlying this disorder are not fully known. This study includes a …
Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo
Aims We hypothesize that specific microRNAs (miRNAs) within cardiomyocyte‐derived
exosomes play a pivotal role in the phenoconversion of cardiac myofibroblasts following …
exosomes play a pivotal role in the phenoconversion of cardiac myofibroblasts following …
No time to die—how islets meet their demise in transplantation
Islet transplantation represents an effective treatment for patients with type 1 diabetes
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …
Interferon alpha: The key trigger of type 1 diabetes
IFNα is a cytokine essential to a vast array of immunologic processes. Its induction early in
the innate immune response provides a priming mechanism that orchestrates numerous …
the innate immune response provides a priming mechanism that orchestrates numerous …
Molecular aspects of pancreatic β‐cell dysfunction: oxidative stress, microRNA, and long noncoding RNA
Metabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This
disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction …
disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction …