The interaction of cells within their microenvironmental niche is fundamental to cell
migration, positioning, growth and differentiation in order to form and maintain complex …

Stimulated Raman scattering (SRS) microscopy is a nonlinear optical imaging method for
visualizing chemical content based on molecular vibrational bonds. Featuring high speed …

Nonlinear optical microscopy has become a powerful tool in bioimaging research due to its
unique capabilities of deep optical sectioning, high‐spatial‐resolution imaging, and 3D …

Lipid bodies have an important role in energy storage and lipid regulation. Here we show
that lipid bodies are a major source of contrast in third-harmonic generation (THG) …

Several biologically important protein structures give rise to strong second-harmonic
generation (SHG) in their native context. In addition to high-contrast optical sections of cells …

Quantifying cell behaviors in animal early embryogenesis remains a challenging issue
requiring in toto imaging and automated image analysis. We designed a framework for …

Loss of myelin in the central nervous system (CNS) leads to debilitating neurological deficits.
High-resolution optical imaging of myelin in the CNS of animal models is limited by a lack of …

Because each nonlinear optical (NLO) imaging modality is sensitive to specific molecules or
structures, multimodal NLO imaging capitalizes the potential of NLO microscopy for studies …

Optical second-and third-harmonic generations have attracted a lot of attention in the
biomedical imaging research field recently due to their intrinsic sectioning ability and …

Second-harmonic generation (SHG) microscopy began to emerge as a high-resolution
optical imaging modality in the late 1990s, about 10 years after two-photon excited …