Activation of transcription requires alteration of chromatin by complexes that increase the
accessibility of nucleosomal DNA. Removing nucleosomes from regulatory sequences has …

Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity.
The histone variant H2A. Z has been shown to contribute to this regulation, but its role has …

The nucleosome is a major modulator of DNA accessibility to other cellular factors.
Nucleosome positioning has a critical importance in regulating cell processes such as …

The eukaryotic genome is organized into nucleosomes, the fundamental units of chromatin.
The positions of nucleosomes on DNA regulate protein-DNA interactions and in turn …

The organization of nucleosomes across functional genomic elements represents a critical
layer of control. Here, we present a strategy for high-resolution nucleosome profiling at …

Chromatin remodelers are ATP-dependent enzymes that are critical for reorganizing and
repositioning nucleosomes in concert with many basic cellular processes. For the …

It has now been over twenty years since a novel herpesviral genome was identified in
Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular …

We show that the physical distribution of nucleosomes at antigen receptor loci is subject to
regulated cell type-specific and lineage-specific positioning and correlates with the …

Nucleosomes are fundamental units of chromatin that play critical roles in gene regulation
by modulating DNA accessibility. However, their roles in regulating tissue-specific gene …

Retroviral integrases (INs) catalyse the integration of the reverse transcribed viral DNA into
the host cell genome. This process is selective, and chromatin has been proposed to be a …