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Oxidative stress in ischemia/reperfusion injuries following acute ischemic stroke
Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …
However, in about one third of these patients, recanalization is followed by …
[HTML][HTML] Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning
T Kalogeris, Y Bao, RJ Korthuis - Redox biology, 2014 - Elsevier
Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …
Nitric oxide and peroxynitrite in health and disease
The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …
[HTML][HTML] The role of the nitric oxide pathway in brain injury and its treatment—from bench to bedside
Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …
review summarises current evidence regarding the role of NO in the regulation of cerebral …
SOD2 in mitochondrial dysfunction and neurodegeneration
The brain is a highly metabolically active tissue that critically relies on oxidative
phosphorylation as a means for maintaining energy. One result of this process is the …
phosphorylation as a means for maintaining energy. One result of this process is the …
Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health
Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …
damaging pathways in different tissues. In addition, mitochondria are an important target of …
Nrf2—a promising therapeutic target for defensing against oxidative stress in stroke
R Zhang, M Xu, Y Wang, F **e, G Zhang, X Qin - Molecular Neurobiology, 2017 - Springer
Stroke is one of the leading causes of death and disability in the world. Oxidative stress,
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …
Therapeutic applications of compounds in the Magnolia family
The bark and/or seed cones of the Magnolia tree have been used in traditional herbal
medicines in Korea, China and Japan. Bioactive ingredients such as magnolol, honokiol, 4 …
medicines in Korea, China and Japan. Bioactive ingredients such as magnolol, honokiol, 4 …
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …
clinical settings and in various animal models of neurological disease. Following calorie …
The influence of common free radicals and antioxidants on development of Alzheimer's Disease
KA Wojtunik-Kulesza, A Oniszczuk, T Oniszczuk… - Biomedicine & …, 2016 - Elsevier
Alzheimer's Disease (AD) is one of the most important neurodegenerative disorders in the
21st century for the continually aging population. Despite an increasing number of patients …
21st century for the continually aging population. Despite an increasing number of patients …