Polycythemia vera: historical oversights, diagnostic details, and therapeutic views

A Tefferi, AM Vannucchi, T Barbui - Leukemia, 2021 - nature.com
Polycythemia vera (PV) is a relatively indolent myeloid neoplasm with median survival that
exceeds 35 years in young patients, but its natural history might be interrupted by …

Appropriate management of polycythaemia vera with cytoreductive drug therapy: European LeukemiaNet 2021 recommendations

M Marchetti, AM Vannucchi, M Griesshammer… - The Lancet …, 2022 - thelancet.com
Polycythaemia vera is associated with a reduced quality of life, a high rate of vascular
events, and an intrinsic risk of disease evolution. The results of several randomised trials for …

Polycythemia vera: 2024 update on diagnosis, risk‐stratification, and management

A Tefferi, T Barbui - American journal of hematology, 2023 - Wiley Online Library
Abstract Disease Overview Polycythemia vera (PV) is a JAK2‐mutated myeloproliferative
neoplasm characterized by clonal erythrocytosis; other features include leukocytosis …

The international consensus classification of myeloid neoplasms and acute leukemias: myeloproliferative neoplasms

J Thiele, HM Kvasnicka, A Orazi… - American journal of …, 2023 - Wiley Online Library
A group of international experts, including hematopathologists, oncologists, and geneticists
were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World …

Genetic basis and molecular profiling in myeloproliferative neoplasms

D Luque Paz, R Kralovics, RC Skoda - Blood, 2023 - ashpublications.org
Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Distinct clinico-molecular arterial and venous thrombosis scores for myeloproliferative neoplasms risk stratification

H Pasquer, R Daltro de Oliveira, L Vasseur… - Leukemia, 2024 - nature.com
Current recommended risk scores to predict thrombotic events associated with
myeloproliferative neoplasms (MPN) do not discriminate between arterial and venous …

Moving toward disease modification in polycythemia vera

JP Bewersdorf, J How, L Masarova, P Bose… - Blood, 2023 - ashpublications.org
Polycythemia vera (PV) belongs to the BCR-ABL1–negative myeloproliferative neoplasms
and is characterized by activating mutations in JAK2 and clinically presents with …

An alternative dosing strategy for ropeginterferon alfa-2b may help improve outcomes in myeloproliferative neoplasms: an overview of previous and ongoing studies …

A Qin, RW Urbanski, L Yu, T Ahmed… - Frontiers in …, 2023 - frontiersin.org
Ropeginterferon alfa-2b is a novel, long-acting mono-pegylated proline-IFN-alpha-2b
approved for treatment of polycythemia vera in adults, regardless of thrombotic risk level or …

[HTML][HTML] Thrombosis in myeloproliferative neoplasms during cytoreductive and antithrombotic drug treatment

T Barbui, A Carobbio, V De Stefano - Research and Practice in Thrombosis …, 2022 - Elsevier
A state‐of‐the‐art lecture titled “Myeloproliferative Neoplasm‐associated Thrombosis” was
presented at the ISTH congress in 2021. We summarize here the main points of the lecture …

ROP-ET: a prospective phase III trial investigating the efficacy and safety of ropeginterferon alfa-2b in essential thrombocythemia patients with limited treatment …

JJ Kiladjian, FF Marin, HK Al-Ali, A Alvarez-Larrán… - Annals of …, 2024 - Springer
Interferon-based therapies, such as ropeginterferon alfa-2b have emerged as promising
disease-modifying agents for myeloproliferative neoplasms (MPNs), including essential …