Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we
still lack a systematic map** from any sequence or variant to regulatory activities. We …

Blockchain technology has the characteristics of decentralization, traceability and tamper-
proof, which creates a reliable decentralized trust mechanism, further accelerating the …

Accurate microbial identification and abundance estimation are crucial for metagenomics
analysis. Various methods for classification of metagenomic data and estimation of …

Accurate cell classification is the groundwork for downstream analysis of single-cell
sequencing data, yet how to identify true marker genes for different cell types still remains a …

Selective breeding of domestic dogs has generated diverse breeds often optimized for
performing specialized tasks. Despite the heritability of breed-typical behavioral traits …

Although adult pluripotent stem cells (aPSCs) are found in many animal lineages,
mechanisms for their formation during embryogenesis are unknown. Here, we leveraged …

As observed in cancers, individual mutagens and defects in DNA repair create distinctive
mutational signatures that combine to form context-specific spectra within cells. We …

Crosslinking mass spectrometry has developed into a robust technique that is increasingly
used to investigate the interactomes of organelles and cells. However, the incomplete and …

Of the several thousand diseases that affect humans, only about 500 have treatments
approved by the US Food and Drug Administration. Even for those with approved …

Sugar porters (SPs) represent the largest group of secondary-active transporters. Some
members, such as the glucose transporters (GLUTs), are well known for their role in …