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Influenza antivirals and their role in pandemic preparedness
Effective antivirals provide crucial benefits during the early phase of an influenza pandemic,
when vaccines are still being developed and manufactured. Currently, two classes of viral …
when vaccines are still being developed and manufactured. Currently, two classes of viral …
[HTML][HTML] Recent advances in molecular mechanisms of nucleoside antivirals
PN Kamzeeva, AV Aralov, VA Alferova… - Current Issues in …, 2023 - mdpi.com
The search for new drugs has been greatly accelerated by the emergence of new viruses
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …
Favipiravir treatment of uncomplicated influenza in adults: results of two phase 3, randomized, double-blind, placebo-controlled trials
Background We conducted double-blind, placebo-controlled trials assessing the efficacy
and tolerability of favipiravir in acute influenza. Methods Otherwise healthy adults with …
and tolerability of favipiravir in acute influenza. Methods Otherwise healthy adults with …
Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiences
Favipiravir, a broad-spectrum RNA-dependent RNA polymerase inhibitor, inhibits the
replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at …
replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at …
Lethal mutagenesis of RNA viruses and approved drugs with antiviral mutagenic activity
In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …
A review on favipiravir: the properties, function, and usefulness to treat COVID-19
Introduction At this time, there is no specific therapeutic or vaccine for treatment of the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hence, available drugs for …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hence, available drugs for …
Influenza antivirals and animal models
Influenza A and B viruses are among the most prominent human respiratory pathogens.
About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths …
About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths …
Lethal mutagenesis of RNA viruses and approved drugs with antiviral mutagenic activity
In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …
Influenza polymerase inhibitor resistance: Assessment of the current state of the art-A report of the isirv Antiviral group
It is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were
approved for the treatment and prevention of influenza. Guidelines for global surveillance …
approved for the treatment and prevention of influenza. Guidelines for global surveillance …
[HTML][HTML] Favipiravir induces HuNoV viral mutagenesis and infectivity loss with clinical improvement in immunocompromised patients
Chronic human norovirus (HuNoV) infections in immunocompromised patients result in
severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase …
severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase …