TERT gene: its function and dysregulation in cancer
In this review, we summarise the function and structure of telomerase reverse transcriptase
(TERT) in humans, including its regulation. The dysregulation of telomerase through TERT …
(TERT) in humans, including its regulation. The dysregulation of telomerase through TERT …
The current state of molecular testing in the BRAF-mutated melanoma landscape
I Vanni, ET Tanda, F Spagnolo, V Andreotti… - Frontiers in Molecular …, 2020 - frontiersin.org
The incidence of melanoma, among the most lethal cancers, is widespread and increasing.
Metastatic melanoma has a poor prognosis, representing about 90% of skin cancer …
Metastatic melanoma has a poor prognosis, representing about 90% of skin cancer …
TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
K Muralidharan, A Yekula, JL Small, ZS Rosh… - Clinical Cancer …, 2021 - AACR
Purpose: Liquid biopsy offers a minimally invasive tool to diagnose and monitor the
heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT …
heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT …
Circulating tumor DNA (ctDNA) detection is associated with shorter progression-free survival in advanced melanoma patients
Abstract BRAF, NRAS and TERT mutations occur in more than 2/3 of melanomas. Its
detection in patient's blood, as circulating tumor DNA (ctDNA), represents a possibility for …
detection in patient's blood, as circulating tumor DNA (ctDNA), represents a possibility for …
Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients
Abstract Background Circulating tumour DNA (ctDNA) may serve as a measure of tumour
burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not …
burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not …
Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection
Extracellular vesicles (EVs), particularly nano-sized small EV exosomes, are emerging
biomarker sources. However, due to heterogeneous populations secreted from diverse cell …
biomarker sources. However, due to heterogeneous populations secreted from diverse cell …
Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells
Abstract Background Circulating tumour cells (CTCs) can be assessed through a minimally
invasive blood sample with potential utility as a predictive, prognostic and …
invasive blood sample with potential utility as a predictive, prognostic and …
Cell-free DNA as a prognostic biomarker for monitoring muscle-invasive bladder cancer
R Carrasco, M Ingelmo-Torres, A Gómez… - International journal of …, 2022 - mdpi.com
Cell-free DNA (cfDNA) has recently emerged as a real-time biomarker for diagnosis,
monitoring and prediction of therapy response in tumoral disease. Here, we evaluated …
monitoring and prediction of therapy response in tumoral disease. Here, we evaluated …
Human TERT promoter mutations as a prognostic biomarker in glioma
The TERT promoter (pTERT) mutations, C228T and C250T, play a significant role in
malignant transformation by telomerase activation, oncogenesis and immortalisation of cells …
malignant transformation by telomerase activation, oncogenesis and immortalisation of cells …
Liquid biopsy in melanoma: significance in diagnostics, prediction and treatment monitoring
Liquid biopsy is a common term referring to circulating tumor cells and other biomarkers,
such as circulating tumor DNA (ctDNA) or extracellular vesicles. Liquid biopsy presents a …
such as circulating tumor DNA (ctDNA) or extracellular vesicles. Liquid biopsy presents a …