Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal
cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and …

Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1. 5),
has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated …

Calcium (Ca2+) sparks are the elementary events of excitation–contraction coupling, yet
they are not explicitly represented in human ventricular myocyte models. A stochastic …

Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca2+-binding protein
expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 …

Bacterial toxins can cause cardiomyopathy, though it is not its most common cause. Some
bacterial toxins can form pores in the membrane of cardiomyocytes, while others can bind to …

Calcium (Ca2+) plays a central role in the excitation and contraction of cardiac myocytes.
Experiments have indicated that calcium release is stochastic and regulated locally …

Cardiovascular disease is the leading cause of death worldwide due in a large part to
arrhythmia. In order to understand how calcium dynamics play a role in arrhythmogenesis …

Transverse aortic constriction (TAC) is one of the experimental mouse models that are
designed to investigate cardiac hypertrophy and heart failure. Most of the studies with this …

Calcium sparks are the elementary Ca2+ release events in excitation-contraction coupling
that underlie the Ca2+ transient. The frequency-dependent contractile force generated by …

Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac
arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic …