Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

People with schizophrenia die 15‐20 years prematurely. Understanding mortality risk and
aggravating/attenuating factors is essential to reduce this gap. We conducted a systematic …

People with severe mental illness (SMI)–schizophrenia, bipolar disorder and major
depressive disorder–appear at risk for cardiovascular disease (CVD), but a comprehensive …

Excess mortality in persons with severe mental disorders (SMD) is a major public health
challenge that warrants action. The number and scope of truly tested interventions in this …

Importance It has remained unclear whether there are clinically meaningful differences
between antipsychotic treatments with regard to preventing relapse of schizophrenia, owing …

Background: Dose equivalents of antipsychotics are an important but difficult to define
concept, because all methods have weaknesses and strongholds. Methods: We calculated …

People with severe mental illness have a considerably shorter lifespan than the general
population. This excess mortality is mainly due to physical illness. Next to mental illness …

The long‐term benefit‐to‐risk ratio of sustained antipsychotic treatment for schizophrenia
has recently been questioned. In this paper, we critically examine the literature on the long …

Background Severe mental illness (SMI; schizophrenia, bipolar disorders (BDs), and other
nonorganic psychoses) is associated with increased risk of cardiovascular disease (CVD) …

Schizophrenia is the eighth leading cause of disability worldwide in people aged 15–44
years. Before antidopaminergic antipsychotics were introduced in the 1950s, no effective …