Nexus between PI3K/AKT and estrogen receptor signaling in breast cancer
Simple Summary Breast cancers are broadly classified into two subtypes: estrogen receptor-
positive and estrogen receptor-negative. Approximately 70% of breast cancers are estrogen …
positive and estrogen receptor-negative. Approximately 70% of breast cancers are estrogen …
PI3K in stemness regulation: from development to cancer
RR Madsen - Biochemical Society Transactions, 2020 - portlandpress.com
The PI3K/AKT pathway is a key target in oncology where most efforts are focussed on
phenotypes such as cell proliferation and survival. Comparatively, little attention has been …
phenotypes such as cell proliferation and survival. Comparatively, little attention has been …
Live-cell measurements of kinase activity in single cells using translocation reporters
Although kinases are important regulators of many cellular processes, measuring their
activity in live cells remains challenging. We have developed kinase translocation reporters …
activity in live cells remains challenging. We have developed kinase translocation reporters …
PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells
Platelet-derived growth factors (PDGFs) regulate embryonic development, tissue
regeneration, and wound healing through their binding to PDGF receptors, PDGFRα and …
regeneration, and wound healing through their binding to PDGF receptors, PDGFRα and …
Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity-associated type 2 diabetes
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic
fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers …
fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers …
[HTML][HTML] Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
SA Vlahopoulos - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
The role of the transcription factor NF-κB in sha** the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …
Cracking the context-specific PI3K signaling code
Specificity in signal transduction is determined by the ability of cells to “encode” and
subsequently “decode” different environmental signals. Akin to computer software, this …
subsequently “decode” different environmental signals. Akin to computer software, this …
Serine phosphorylation by mTORC1 promotes IRS-1 degradation through SCFβ-TRCP E3 ubiquitin ligase
Y Yoneyama, T Inamitsu, K Chida, SI Iemura… - IScience, 2018 - cell.com
The insulin receptor substrate IRS-1 is a key substrate of insulin and insulin-like growth
factor (IGF) receptor tyrosine kinases that mediates their metabolic and growth-promoting …
factor (IGF) receptor tyrosine kinases that mediates their metabolic and growth-promoting …
PI3K signaling through a biochemical systems lens
Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that
the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by …
the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by …
A highly sensitive fluorescent Akt biosensor reveals lysosome-selective regulation of lipid second messengers and kinase activity
The serine/threonine protein kinase Akt regulates a wide range of cellular functions via
phosphorylation of various substrates distributed throughout the cell, including at the plasma …
phosphorylation of various substrates distributed throughout the cell, including at the plasma …