[HTML][HTML] mTORC1 couples cyst (e) ine availability with GPX4 protein synthesis and ferroptosis regulation

Y Zhang, RV Swanda, L Nie, X Liu, C Wang… - Nature …, 2021 - nature.com
Abstract Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid
peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 …

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance

F Wei, D Wang, J Wei, N Tang, L Tang, F **ong… - Cellular and Molecular …, 2021 - Springer
The successful treatment of human cancers by immunotherapy has been made possible by
breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD …

Starve cancer cells of glutamine: break the spell or make a hungry monster?

J Jiang, S Srivastava, J Zhang - Cancers, 2019 - mdpi.com
Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and
utilization to accommodate their elevated demands for biosynthesis and energy production …

Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients

JH Kong, H Lee, D Kim, SK Han, D Ha, K Shin… - Nature …, 2020 - nature.com
Cancer patient classification using predictive biomarkers for anti-cancer drug responses is
essential for improving therapeutic outcomes. However, current machine-learning-based …

Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration

V Kluever, B Russo, S Mandad, NH Kumar… - Science …, 2022 - science.org
Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …

The effects of metabolism on the immune microenvironment in colorectal cancer

X Chen, Z Ma, Z Yi, E Wu, Z Shang, B Tuo, T Li… - Cell Death …, 2024 - nature.com
Colorectal cancer (CRC) is a malignancy that is widely prevalent worldwide. Due to its
unsatisfactory treatment outcome and extremely poor prognosis, many studies on the …

Amino acid variability, tradeoffs and optimality in human diet

Z Dai, W Zheng, JW Locasale - Nature communications, 2022 - nature.com
Studies at the molecular level demonstrate that dietary amino acid intake produces
substantial effects on health and disease by modulating metabolism. However, how these …

1H NMR-based metabolomics of paired tissue, serum and urine samples reveals an optimized panel of biofluids metabolic biomarkers for esophageal cancer

T Ouyang, C Ma, Y Zhao, W Ye, J Zhao, R Cai… - Frontiers in …, 2023 - frontiersin.org
Introduction The goal of this study was to establish an optimized metabolic panel by
combining serum and urine biomarkers that could reflect the malignancy of cancer tissues to …

A novel prognostic related lncRNA signature associated with amino acid metabolism in glioma

Q Lei, B Yuan, K Liu, L Peng, Z **a - Frontiers in Immunology, 2023 - frontiersin.org
Background Glioma is one of the deadliest malignant brain tumors in adults, which is highly
invasive and has a poor prognosis, and long non-coding RNAs (lncRNAs) have key roles in …

Aspartate-glutamate carrier 2 (citrin): A role in glucose and amino acid metabolism in the liver

M Holeček - BMB reports, 2023 - pmc.ncbi.nlm.nih.gov
Aspartate-glutamate carrier 2 (AGC2, citrin) is a mitochondrial carrier expressed in the liver
that transports aspartate from mitochondria into the cytosol in exchange for glutamate. The …