Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Metabolism has recently emerged as a major target of genes implicated in the evolutionary
expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

SYNAPTIC transmission of most vertebrate synapses is thought to be terminated by rapid
transport of the neurotransmitter into presynaptic nerve terminals or neuroglia1–5. L …

l-Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous
system (CNS) and is stored in synaptic vesicles by an uptake system that is dependent on …

ABSTARCT dl-threo-β-Benzyloxyaspartate (dl-TBOA), a novel derivative of dl-threo-β-
hydroxyaspartate, was synthesized and examined as an inhibitor of sodium-dependent …

Defects in neurotransmitter glutamate transport may be an important component of chronic
neurotoxicity in diseases such as amyotrophic lateral sclerosis. There are no reliable models …

Little is known of the molecular mechanisms that trigger oligodendrocyte death and
demyelination in many acute central nervous system insults. Since oligodendrocytes …