Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

The retina is an immune privileged tissue, which is protected from external and internal
insults by its blood-retina barriers and immune suppressive microenvironment. Apart from …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

Microglia, the resident immune cells of the central nervous system (CNS), have received
significant attention due to their critical roles in maintaining brain homeostasis and …

Microglia are emerging as a key cell type in neurodegenerative diseases, yet human
microglia are challenging to study in vitro. We developed an in vitro cell model system …

In contrast to the tremendous amount of research data from the central nervous system,
relatively little is known about microglial homeostasis in the retina. This may be explained by …

Cell migration participates in a variety of physiological and pathological processes such as
embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue …

Microglia are the sentinels of the brain but a clear understanding of the factors that modulate
their activation in physiological and pathological conditions is still lacking. Here we …

Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in
humans, produced by the adrenals, the gonads and the brain. DHEA was previously shown …