Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Fucoidan is a natural derived compound found in different species of brown algae and in
some animals, that has gained attention for its anticancer properties. However, the exact …

Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

RAS proteins are small GTPases known for their involvement in oncogenesis: around 25%
of human tumors present mutations in a member of this family. RAS operates in a complex …

Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …

PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations
have not been defined. To evaluate the consequences of PIK3CA alterations, the two most …

Organo-seleno compounds (org-Se) have been widely used in antitumor, antiviral, and
antiinflammatory therapy; antioxidation and other biological fields. As such, they have made …

Both pro-and antioncogenic properties have been attributed to EphA2 kinase. We report that
a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in …